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مقاله شماره 20

 

Abstract

Introduction:

Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E and HMB-45.

 

 

 

 

 

 

 

 

 

 

 

 

Methods:

 

Thirty subjects with non-segmental vitiligo lesions were treated twice a week for 6 weeks with 308-nm MEL, while NB-UVB was used to treat lesions contra laterally. Skin biopsies were taken from lesional areas before and after 6 weeks of treatment by either modality. It was prepared for light microscopy and immunohistochemical study (HMB-45). This study was performed as a clinical trial (Trial registration: http://www.pactr.org; Identifier: PACTR201705002279419)

Results:

 

All lesions before treatment had labeling index (number of pigmented cells/non-pigmented cells) of 0.0 (0%). After treatment the LI for MEL was 4.2 ± 2.6, while for NB-UVB LI it was 0.3 ± 0.7. MEL showed higher statistical significance regarding increase of basal pigmented cells, and significant decrease in vacuolated keratinocytes and basal membrane thickness than NB-UVB.

Conclusion:

 

Although NB-UVB is considered as treatment of choice for vitiligo, MEL is acknowledged as an effective treatment modality for vitiliginous lesions that induces more repigmentation than NB-UVB, and more rapidly, as confirmed by our study.

Keywords:

 

Excimer laser; Haematoxylin & Eosin (H&E); Human melanoma black-45 (HMB -45); Phototherapy; Narrow band ultra-violet B (NB-UVB); Vitiligo.

see more: http://journals.sbmu.ac.ir/jlms/article/view/13606/4


٠٩:٢٨ - 1396/06/05    /    شماره : ١٥٠    /    تعداد نمایش : ٤١


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